diff --git a/mindspore/ccsrc/pre_activate/pass/optimize_dependence.cc b/mindspore/ccsrc/pre_activate/pass/optimize_dependence.cc
index 6ae3f3be36..db32354abf 100644
--- a/mindspore/ccsrc/pre_activate/pass/optimize_dependence.cc
+++ b/mindspore/ccsrc/pre_activate/pass/optimize_dependence.cc
@@ -27,6 +27,69 @@
 namespace mindspore {
 namespace opt {
 constexpr auto kSingleInputIndex = 1;
+namespace {
+AnfNodePtr GetReplaceNode(const FuncGraphPtr &func_graph, const AnfNodePtr &node) {
+  MS_EXCEPTION_IF_NULL(func_graph);
+  MS_EXCEPTION_IF_NULL(node);
+  if (!node->isa<CNode>()) {
+    return nullptr;
+  }
+  auto cnode = node->cast<CNodePtr>();
+  MS_EXCEPTION_IF_NULL(cnode);
+  string op_name = AnfAlgo::GetCNodeName(cnode);
+  // Currently we only eliminate transdata or cast nodes.
+  if (op_name != kTransDataOpName && op_name != prim::kPrimCast->name()) {
+    return nullptr;
+  }
+  auto manager = func_graph->manager();
+  MS_EXCEPTION_IF_NULL(manager);
+  // Check whether the node has only one output node.
+  if (manager->node_users().find(cnode) == manager->node_users().end()) {
+    MS_LOG(EXCEPTION) << "The node should be used by at least another node's input";
+  }
+  if (manager->node_users()[cnode].size() > 1) {
+    return nullptr;
+  }
+  CheckCNodeInputSize(cnode, kSingleInputIndex + 1);
+  return cnode->input(kSingleInputIndex);
+}
+
+bool ReplaceMakeTuple(const FuncGraphPtr &func_graph, const CNodePtr &cnode) {
+  MS_EXCEPTION_IF_NULL(func_graph);
+  MS_EXCEPTION_IF_NULL(cnode);
+  if (AnfAlgo::GetCNodeName(cnode) != prim::kPrimMakeTuple->name()) {
+    return false;
+  }
+  std::vector<AnfNodePtr> new_make_tuple_inputs;
+  bool need_update = false;
+  for (const auto &input : cnode->inputs()) {
+    AnfNodePtr replace_input = GetReplaceNode(func_graph, input);
+    // If replace input is not null, it will be the input of the TransData or Cast.
+    if (replace_input == nullptr) {
+      new_make_tuple_inputs.push_back(input);
+      continue;
+    }
+    new_make_tuple_inputs.push_back(replace_input);
+    need_update = true;
+  }
+  if (need_update) {
+    auto kernel_graph = func_graph->cast<std::shared_ptr<session::KernelGraph>>();
+    CNodePtr new_make_tuple = nullptr;
+    if (kernel_graph == nullptr) {
+      new_make_tuple = func_graph->NewCNode(new_make_tuple_inputs);
+    } else {
+      new_make_tuple = kernel_graph->NewCNode(cnode);
+    }
+    MS_EXCEPTION_IF_NULL(new_make_tuple);
+    new_make_tuple->set_inputs(new_make_tuple_inputs);
+    auto manager = func_graph->manager();
+    MS_EXCEPTION_IF_NULL(manager);
+    manager->Replace(cnode, new_make_tuple);
+  }
+  return true;
+}
+}  // namespace
+
 const BaseRef OptimizeDependence::DefinePattern() const {
   VarPtr X = std::make_shared<Var>("X");
   MS_EXCEPTION_IF_NULL(X);
@@ -43,9 +106,8 @@ const AnfNodePtr OptimizeDependence::Process(const FuncGraphPtr &func_graph, con
     return nullptr;
   }
   auto depend_cnode = node->cast<CNodePtr>();
-  if (depend_cnode->inputs().size() < kDependInputNum) {
-    return nullptr;
-  }
+  MS_EXCEPTION_IF_NULL(depend_cnode);
+  CheckCNodeInputSize(depend_cnode, kDependInputNum);
   auto replacing_node = depend_cnode->input(kDependInputNum - 1);
   MS_EXCEPTION_IF_NULL(replacing_node);
   if (!replacing_node->isa<CNode>()) {
@@ -53,36 +115,29 @@ const AnfNodePtr OptimizeDependence::Process(const FuncGraphPtr &func_graph, con
   }
   auto replacing_cnode = replacing_node->cast<CNodePtr>();
   MS_EXCEPTION_IF_NULL(replacing_cnode);
-  // Currently we only optimize transdata or cast nodes.
-  string replacing_cnode_op_name = AnfAlgo::GetCNodeName(replacing_cnode);
-  if (replacing_cnode_op_name != kTransDataOpName && replacing_cnode_op_name != prim::kPrimCast->name()) {
+  // Deal with the make_tuple with TransData or Cast inputs.
+  if (ReplaceMakeTuple(func_graph, replacing_cnode)) {
     return nullptr;
   }
-  auto manager = func_graph->manager();
-  MS_EXCEPTION_IF_NULL(manager);
-  // Check whether the replacing node has only one input and one output.
-  if (replacing_cnode->inputs().size() != kSingleInputIndex + 1) {
-    return nullptr;
-  }
-  if (manager->node_users().find(replacing_node) == manager->node_users().end()) {
-    MS_LOG(EXCEPTION) << "The node should be used by at least another node input";
-  }
-  if (manager->node_users()[replacing_node].size() > 1) {
+  AnfNodePtr replace_node = GetReplaceNode(func_graph, replacing_cnode);
+  if (replace_node == nullptr) {
+    MS_LOG(DEBUG) << "Can not find the TransData or Cast with single output node. Depend node: " << node->DebugString();
     return nullptr;
   }
   std::vector<AnfNodePtr> new_depend_inputs = {depend_cnode->input(kAnfPrimitiveIndex),
-                                               depend_cnode->input(kRealInputIndexInDepend),
-                                               replacing_cnode->input(kSingleInputIndex)};
+                                               depend_cnode->input(kRealInputIndexInDepend), replace_node};
   auto kernel_graph = func_graph->cast<std::shared_ptr<session::KernelGraph>>();
   CNodePtr new_depend;
   if (kernel_graph == nullptr) {
     new_depend = func_graph->NewCNode(new_depend_inputs);
+    MS_EXCEPTION_IF_NULL(new_depend);
+    new_depend->set_abstract(node->abstract());
+    new_depend->set_scope(node->scope());
   } else {
     new_depend = kernel_graph->NewCNode(depend_cnode);
     MS_EXCEPTION_IF_NULL(new_depend);
     new_depend->set_inputs(new_depend_inputs);
   }
-  new_depend->set_abstract(node->abstract());
   return new_depend;
 }
 }  // namespace opt
diff --git a/tests/ut/cpp/pre_activate/pass/optimize_dependence_test.cc b/tests/ut/cpp/pre_activate/pass/optimize_dependence_test.cc
index 3f59b6159a..e95d63e93e 100644
--- a/tests/ut/cpp/pre_activate/pass/optimize_dependence_test.cc
+++ b/tests/ut/cpp/pre_activate/pass/optimize_dependence_test.cc
@@ -48,5 +48,25 @@ TEST_F(TestHWOptimizeDependence, test_optimize_dependence) {
   FuncGraphPtr g_after = get_py_fun_.CallAndParseRet("test_optimize_dependence", "after");
   EXPECT_TRUE(CheckEqualGraph(g_after, new_graph));
 }
+
+TEST_F(TestHWOptimizeDependence, test_optimize_dependence_with_make_tuple) {
+  /*
+   * def before(x, y, a, b):
+   *    z = make_tuple(TransData(a), TransData(b))
+   *    depend_intput = depend(y, z)
+   *    sum = add(x, depend_intput)
+   *    return sum
+   */
+  FuncGraphPtr g = get_py_fun_.CallAndParseRet("test_optimize_dependence_with_make_tuple", "before");
+
+  auto optimizer = std::make_shared<opt::GraphOptimizer>();
+  auto pm = std::make_shared<opt::PassManager>();
+  pm->AddPass(std::make_shared<opt::OptimizeDependence>());
+  optimizer->AddPassManager(pm);
+  FuncGraphPtr new_graph = optimizer->Optimize(g);
+
+  FuncGraphPtr g_after = get_py_fun_.CallAndParseRet("test_optimize_dependence_with_make_tuple", "after");
+  EXPECT_TRUE(CheckEqualGraph(g_after, new_graph));
+}
 }  // namespace opt
 }  // namespace mindspore
diff --git a/tests/ut/cpp/python_input/gtest_input/pre_activate/optimize_dependence_test.py b/tests/ut/cpp/python_input/gtest_input/pre_activate/optimize_dependence_test.py
index 45c419d25d..05eb057327 100644
--- a/tests/ut/cpp/python_input/gtest_input/pre_activate/optimize_dependence_test.py
+++ b/tests/ut/cpp/python_input/gtest_input/pre_activate/optimize_dependence_test.py
@@ -18,6 +18,8 @@ from mindspore.ops import Primitive
 depend = Primitive('depend')
 TransData = Primitive('TransData')
 add = P.TensorAdd()
+make_tuple = Primitive('make_tuple')
+
 
 class FnDict:
     def __init__(self):
@@ -47,3 +49,23 @@ def test_optimize_dependence(tag):
         return sum
 
     return fns[tag]
+
+
+def test_optimize_dependence_with_make_tuple(tag):
+    fns = FnDict()
+
+    @fns
+    def before(x, y, a, b):
+        z = make_tuple(TransData(a), TransData(b))
+        depend_intput = depend(y, z)
+        sum = add(x, depend_intput)
+        return sum
+
+    @fns
+    def after(x, y, a, b):
+        z = make_tuple(a, b)
+        depend_intput = depend(y, z)
+        sum = add(x, depend_intput)
+        return sum
+
+    return fns[tag]